Secret Service Agent Rory Calhoun has the dream assignment of her career - protecting the President of the United States. Until early one morning, the President vanishes right out of the Oval Office, seemingly into thin air. Was President Jackson Boone kidnapped? Or did he orchestrate the disappearance himself?
As the White House launches into damage control, they are hit with a second blow. The president's daughter - a student at a New England university where days before a Nobel-prize winning physicist was brutally tortured and murdered - is also missing.
Later that morning, a devastating earthquake and tsunami strike Lisbon, Portugal, and an increasingly desperate White House is finding it harder and harder to keep a lid on the President's disappearance. As Rory goes back over the last forty-eight hours, one unusual thing jumps out at her: a seemingly off-hand request by the president to his staff to find out everything they can about something called the Pandora Effect . . .